Summary: Regenerative injection therapy (prolotherapy) is a treatment modality that can help cure chronic pain when it is the result of specific musculoskeletal causes. Chronic pain has no physiologic or protective role in humans and becomes a disease if not relieved during its acute stage. It therefore demands a change in treatment strategy and requires physicians to focus on the pain as a chronic disease and not an acute illness. Modifying the underlying physiology is often the only way to modify this pain. By recruiting the body's own healing forces, new connective tissue can be generated at specific locations that can change the natural history of the chronic pain. Regenerative injection therapy is a treatment that has helped thousands of patients overcome their chronic pain.