Impact of Autologous Bone Marrow-Derived Stem Cells on Degenerative Changes of Articulating Surfaces Associated With the Arthritic Temporomandibular Joint: An Experimental Study in Rabbits

This study evaluated the effect of bone marrow-derived stem cells (BMSCs) on degenerative changes of TMJ associated with bovine collagen type II (BCII) induced-arthritis.

Materials and Methods

Fifty rabbits were divided into 3 groups. Group I (n = 10) received no treatment. Group II (n = 20) was divided into 2 subgroups according to treatment type. One subgroup (n = 10) received an intra-articular (IA) injection of phosphate buffered saline (PBS) and the other (n = 10) received an IA injection of PBS plus BMSCs. Group III (n = 20) received an injection of oil emulsion of BCII before treatment with PBS or PBS plus BMSCs as in group II. Rabbits were euthanized after the third week and the joints were processed for histology.