The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer’s disease

The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-β peptide (Aβ) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism…

Continue ReadingThe therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer’s disease

Repeated peripheral administration of adult mesenchymal stem cells has a positive impact on Abeta amyloid pathology in a transgenic mouse model of Alzheimer’s disease

Alzheimer's disease (AD) is a neurodegenerative disorder pathologically characterized by extracellular senile plaques, primarily composed of polymerized amyloid-beta (Abeta) peptides. There is currently no cure for this disease that represents…

Continue ReadingRepeated peripheral administration of adult mesenchymal stem cells has a positive impact on Abeta amyloid pathology in a transgenic mouse model of Alzheimer’s disease

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses†‡§

Alzheimer's disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been suggested as…

Continue ReadingIntracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses†‡§

Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells

Purpose To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC). Methods Fourteen consecutive patients (9 women,…

Continue ReadingConventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells