Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization

OBJECTIVE: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent. High sensitization rates were observed in contact-allergic patients…

Continue ReadingHomozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization

Activity and Expression of Glutathione S-transferase Pi in Patients With Amyotrophic Lateral Sclerosis

Glutathione S-transferase (GST, EC 2.5.1.18) is an enzyme responsible for inactivation of a large variety of toxic, electrophilic compounds and organic peroxides. GST activity and GST pi expression were studied…

Continue ReadingActivity and Expression of Glutathione S-transferase Pi in Patients With Amyotrophic Lateral Sclerosis

Glutathione Depletion and In Vitro Lipid Peroxidation in Mercury or Maleate Induced Acute Renal Failure

Nephrotoxic acute renal failure was experimentally induced in male rats by s.c. application of mercuric chloride and i.p. administration of maleate, respectively. Mercuric chloride and maleate are known to enhance…

Continue ReadingGlutathione Depletion and In Vitro Lipid Peroxidation in Mercury or Maleate Induced Acute Renal Failure