Depletion of Glutathione S-transferase P1 Induces Apoptosis in Human Lung Fibroblasts

Glutathione S-transferase P1 (GSTP1) is one of the xenobiotic-metabolizing and antioxidant enzymes, identified in the peripheral lungs. Recently, the authors reported the association between GSTP1 gene polymorphism and susceptibility to…

Continue ReadingDepletion of Glutathione S-transferase P1 Induces Apoptosis in Human Lung Fibroblasts

Competition for Glutathione Precursors Between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue Syndrome

The chronic fatigue syndrome (CFS) is typically associated or follows a recognized or presumed infection. Abnormalities of both humoral and cellular immunity have been demonstrated in a substantial proportion of…

Continue ReadingCompetition for Glutathione Precursors Between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue Syndrome

Glutathione in the Prevention of Cisplatin Induced Toxicities: A Prospectively Randomized Pilot Trial in Patients with Head and Neck Cancer and Non Small Cell Lung Cancer

Purpose: Glutathione has been shown to be an effective chemoprotector against cisplatin-induced side effects in patients with ovarian cancer. In view of this fact, we performed a randomized clinical pilot-trial…

Continue ReadingGlutathione in the Prevention of Cisplatin Induced Toxicities: A Prospectively Randomized Pilot Trial in Patients with Head and Neck Cancer and Non Small Cell Lung Cancer