Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

Background Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from bone marrow with secretory functions of various neurotrophic factors. Stromal cell-derived factor-1α (SDF-1α) is also reported as one of…

Continue ReadingIntravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α

Endometrial stem cell transplantation restores dopamine production in a Parkinson’s disease model

Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons. Adult human endometrial derived stem cells (HEDSC), a readily obtainable type of mesenchymal stem-like cell, were…

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Mesenchymal Stem Cells Augment Neurogenesis in the Subventricular Zone and Enhance Differentiation of Neural Precursor Cells Into Dopaminergic Neurons in the Substantia Nigra of a Parkinsonian Model

Growing evidence has demonstrated that neurogenesis in the subventricular zone (SVZ) is significantly decreased in Parkinson's disease (PD). Modulation of endogenous neurogenesis would have a significant impact on future therapeutic…

Continue ReadingMesenchymal Stem Cells Augment Neurogenesis in the Subventricular Zone and Enhance Differentiation of Neural Precursor Cells Into Dopaminergic Neurons in the Substantia Nigra of a Parkinsonian Model

Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients

Background and aim:  Despite improvements in surgical revascularisation, limitations like anatomical factors or atherosclerosis limit the success of revascularisation in diabetic patients with critical limb ischaemia. Stem cells were shown…

Continue ReadingAutologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients