Cancer

Melatonin modulates the cadmium-induced expression of MT-2 and MT-1 metallothioneins in three lines of human tumor cells (MCF-7, MDA-MB-231 and HeLa)

Cadmium (Cd) is a human carcinogen present in tobacco smoke and contaminated industrial soils. Metallothioneins (MTs) are intracellular proteins involved in protecting against Cd. The toxic effects of Cd can…

Continue ReadingMelatonin modulates the cadmium-induced expression of MT-2 and MT-1 metallothioneins in three lines of human tumor cells (MCF-7, MDA-MB-231 and HeLa)

Melatonin inhibits both ER? activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium

Cadmium (Cd) is a heavy metal affecting human health both through environmental and occupational exposure. There is evidence that Cd accumulates in several organs and is carcinogenic to humans. In…

Continue ReadingMelatonin inhibits both ER? activation and breast cancer cell proliferation induced by a metalloestrogen, cadmium

Lung Cancer Mortality and Polynuclear Aromatic Hydrocarbons: A Case-Cohort Study of Aluminum Production Workers in Arvida, Quebec, Canada

The authors report the results of a case-cohort study of 338 lung cancer deaths in 1950-1988 and a random sample (sub-cohort) of 1,138 from among 16,297 men who had worked…

Continue ReadingLung Cancer Mortality and Polynuclear Aromatic Hydrocarbons: A Case-Cohort Study of Aluminum Production Workers in Arvida, Quebec, Canada