Molecular Replacement in Cancer Therapy: Reversing Cancer Metabolic and Mitochondrial Dysfunction, Fatigue and the Adverse Effects of Cancer Therapy

Abstract: Introduction: Cancers are associated with excess cellular oxidative stress, and during cancer treatment the addition of drug-induced oxidative stress can limit the effectiveness of therapy and cause a number…

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A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients

Background: A polysaccharide extract from Grifola frondosa (Maitake extract) has shown immunomodulatory effects in preclinical studies and potentials for anticancer immunotherapy. However whether its oral administration in human is associated…

Continue ReadingA phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients

Cadmium Promotes Breast Cancer Cell Proliferation by Potentiating the Interaction between ER{alpha} and c-Jun

Cadmium is an environmental contaminant that enters the body through diet or cigarette smoke. It affects multiple cellular processes, including cell proliferation, differentiation, and apoptosis. Recently, cadmium has been shown…

Continue ReadingCadmium Promotes Breast Cancer Cell Proliferation by Potentiating the Interaction between ER{alpha} and c-Jun

The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells

Cadmium (Cd) is a nonessential metal that is dispersed throughout the environment. It is an endocrine-disrupting element which mimics estrogen, binds to estrogen receptor alpha (ERalpha), and promotes cell proliferation…

Continue ReadingThe membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells