Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. This review briefly summarizes the published reports supporting this conclusion.…
Antioxidant enzymes form the first line of defense against free radicals in organisms. Their regulation depends mainly on the oxidant status of the cell, given that oxidants are their principal…
Mercury, cadmium, and other heavy metals have a high affinity for sulfhydryl (-SH) groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (NAC, ALA, GSH), with subsequent decreased oxidant…
Mitochondrial defects have been linked to such devastating neurodegenerative diseases as Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Alzheimer's as well as senile dementia's. Mitochondrial metabolic defects…