Competition for Glutathione Precursors Between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue Syndrome

The chronic fatigue syndrome (CFS) is typically associated or follows a recognized or presumed infection. Abnormalities of both humoral and cellular immunity have been demonstrated in a substantial proportion of…

Continue ReadingCompetition for Glutathione Precursors Between the Immune System and the Skeletal Muscle: Pathogenesis of Chronic Fatigue Syndrome

Depletion of Glutathione S-transferase P1 Induces Apoptosis in Human Lung Fibroblasts

Glutathione S-transferase P1 (GSTP1) is one of the xenobiotic-metabolizing and antioxidant enzymes, identified in the peripheral lungs. Recently, the authors reported the association between GSTP1 gene polymorphism and susceptibility to…

Continue ReadingDepletion of Glutathione S-transferase P1 Induces Apoptosis in Human Lung Fibroblasts

Lipofuscin

Abstract Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging,…

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Environmental Infection and Heavy Metal Analysis in More Than 400 Patients. Part I: Metal Analysis of Aluminium, Lead, Selenium, Zinc

Purpose: Chronic diseases can develop through metabolic disturbances in trace elements and vitamins, and be maintained by environmental toxins. In order to gain more insight into these complex interactions and…

Continue ReadingEnvironmental Infection and Heavy Metal Analysis in More Than 400 Patients. Part I: Metal Analysis of Aluminium, Lead, Selenium, Zinc