Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing.

Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term.…

Continue ReadingIntra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing.

Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells

Purpose To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC). Methods Fourteen consecutive patients (9 women,…

Continue ReadingConventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses†‡§

Alzheimer's disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been suggested as…

Continue ReadingIntracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses†‡§

Repeated peripheral administration of adult mesenchymal stem cells has a positive impact on Abeta amyloid pathology in a transgenic mouse model of Alzheimer’s disease

Alzheimer's disease (AD) is a neurodegenerative disorder pathologically characterized by extracellular senile plaques, primarily composed of polymerized amyloid-beta (Abeta) peptides. There is currently no cure for this disease that represents…

Continue ReadingRepeated peripheral administration of adult mesenchymal stem cells has a positive impact on Abeta amyloid pathology in a transgenic mouse model of Alzheimer’s disease