Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality, worldwide. Given that the foremost risk factor leading to the…

Continue ReadingBiological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease

A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD

Background:  COPD is a devastating disease affecting millions worldwide. As disease pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory effects of systemically administered mesenchymal stem cells (MSCs) may decrease…

Continue ReadingA Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD

Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial

Purpose The management of perianal fistula in patients with Crohn’s disease is an extremely challenging medical problem as many fistulas do not respond to available treatments. The objectives were to…

Continue ReadingExpanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial