Stem cell therapy for peripheral arterial disease
Background Peripheral arterial disease (PAD) is a common cause of disability and mortality. Up to one third of patients are not susceptible to traditional revascularization and may benefit from stem…
Bone Marrow Mesenchymal Stromal Cell Transplantation: A Neurorestorative Therapy for Stroke
A decade long focus on neuroprotection for stroke and neural injury, and its failure to translate into the clinical setting has led to a major shift of focus from neuroprotection…
Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways
Bone marrow-derived mesenchymal stem cells (MSCs) have been identified as one possible strategy for the treatment of chronic obstructive pulmonary disease (COPD). Our previous studies have demonstrated that MSC administration…
A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD
Background: COPD is a devastating disease affecting millions worldwide. As disease pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory effects of systemically administered mesenchymal stem cells (MSCs) may decrease…
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