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Ironing Iron Out in Parkinson’s Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6-Hydroxydopamine and Iron Chelators, Desferal and VK-28

In Parkinson`s disease (PD) and its neurotoxin-induced models, 6-hydroxydopamine (6-OHDA) and N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), significant accumulation of iron occurs in the substantia nigra pars compacta. The iron is thought to be…

Continue ReadingIroning Iron Out in Parkinson’s Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6-Hydroxydopamine and Iron Chelators, Desferal and VK-28

Is Parkinson’s disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

Razor sharp and high iron deposits are present in the substantia nigra (SN). Although the function of such high iron content is not known, the homeostasis of brain iron is…

Continue ReadingIs Parkinson’s disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease.

Levels of iron, copper, zinc, manganese, and lead were measured by inductively coupled plasma spectroscopy in parkinsonian and age-matched control brain tissue. There was 31-35% increase in the total iron…

Continue ReadingIncreased nigral iron content and alterations in other metal ions occurring in brain in Parkinson’s disease.