Chronic sarcoidosis (CS) is often unresponsive to usual treatments. Melatonin, an immunoregulatory drug, was employed in CS patients in whom usual treatments were ineffective or induced severe side effects. Melatonin…
Mitochondrial defects have been linked to such devastating neurodegenerative diseases as Parkinson's, Huntington's, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Alzheimer's as well as senile dementia's. Mitochondrial metabolic defects…
Mercury, cadmium, and other heavy metals have a high affinity for sulfhydryl (-SH) groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (NAC, ALA, GSH), with subsequent decreased oxidant…
Antioxidant enzymes form the first line of defense against free radicals in organisms. Their regulation depends mainly on the oxidant status of the cell, given that oxidants are their principal…