Metabolic biomarkers of Increased Oxidative Stress and Impaired Methylation Capacity in Children with Autism

Background: Autism is a complex neurodevelopmental disorder that usually presents in early childhood and that is thought to be influenced by genetic and environmental factors. Although abnormal metabolism of methionine…

Continue ReadingMetabolic biomarkers of Increased Oxidative Stress and Impaired Methylation Capacity in Children with Autism

Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization

OBJECTIVE: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent. High sensitization rates were observed in contact-allergic patients…

Continue ReadingHomozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization

Activity and Expression of Glutathione S-transferase Pi in Patients With Amyotrophic Lateral Sclerosis

Glutathione S-transferase (GST, EC 2.5.1.18) is an enzyme responsible for inactivation of a large variety of toxic, electrophilic compounds and organic peroxides. GST activity and GST pi expression were studied…

Continue ReadingActivity and Expression of Glutathione S-transferase Pi in Patients With Amyotrophic Lateral Sclerosis