To elucidate the pathogenic mechanisms involved in neurodegeneration in AIDS patients with cognitive deficits, we have examined the toxic effect of the lent ivirus lytic peptide 1 (LLP-1) corresponding to…
Oxidative stress has been implicated in the pathogenesis of human immunodeficiency virus (HIV) infection. We examined the effect of highly active antiretroviral therapy (HAART) on plasma levels of several antioxidants…
Glutathione (-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/ glutathione disulfide is the major redox couple in animal cells. The synthesis of GSH from glutamate, cysteine, and glycine…
The destructive pathologic and biochemical consequences of methyl mercury have been extensively described. Relatively little is known, however, about the defensive mechanisms neurons employ to protect themselves against mercurial injury.…