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Disruption of Thiol Homeostasis and Nitrosative Stress in the Cerebrospinal Fluid of Patients With Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine

Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducible nitric oxide synthase…

Continue ReadingDisruption of Thiol Homeostasis and Nitrosative Stress in the Cerebrospinal Fluid of Patients With Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine

Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid proteinnitrotyrosine and S-nitrosothiols and with changes in glutathione levels

Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated…

Continue ReadingNitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid proteinnitrotyrosine and S-nitrosothiols and with changes in glutathione levels