Oxidative stress is increased in the retina in diabetes, and it is considered to play an important role in the development of retinopathy. α-Lipoic acid, a thiol antioxidant, has been…
Aims/hypothesis Hyperglycaemia-induced mitochondrial overproduction of reactive oxygen species (ROS) is central to the pathogenesis of endothelial damage in diabetes. R-(+)-α-lipoic acid has advantages over classic antioxidants, as it distributes to…
Background — Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound -lipoic acid (LA) exerts antiinflammatory effects by inhibiting…
Abstract: Aims: To determine the efficacy and safety of 600 mg of [alpha]-lipoic acid given intravenously over 3 weeks in diabetic patients with symptomatic polyneuropathy. Methods: We searched the database…