Dietary [alpha]-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats

Background and objectives: In spontaneously hypertensive rats (SHRs), excess endogenous aldehydes bind sulfhydryl groups of membrane proteins, altering membrane Ca2+ channels and increasing cytosolic free calcium and blood pressure. The…

Continue ReadingDietary [alpha]-lipoic acid supplementation lowers blood pressure in spontaneously hypertensive rats

Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine

Abstract The ability of Alpha-Lipoic Acid (ALA) and N-Acetyl Cysteine (NAC), two active antioxidant agents, to correct in vitro the most significant functional defects of peripheral blood mononuclear cells (PBMC)…

Continue ReadingRestoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine

a-Lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise

Antioxidant nutrients have demonstrated potential in protecting against exercise-induced oxidative stress. a-Lipoic acid (LA) is a proglutathione dietary supplement that is known to strengthen the antioxidant network. We studied the…

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Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite…

Continue ReadingLipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer’s disease