Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs

Purpose While the benefits of ascorbic acid (vitamin C, ascorbate) as an essential nutrient are well established, its effects on tumor cells and in tumor treatment are controversial. In particular,…

Continue ReadingAscorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs

Meta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk

Background: Our objective was to conduct a systematic review and meta-analysis of prospective studies on colorectal cancer (CRC) and vitamin D intake and 25-hydroxyvitamin D status, as part of the…

Continue ReadingMeta-Analyses of Vitamin D Intake, 25-Hydroxyvitamin D Status, Vitamin D Receptor Polymorphisms, and Colorectal Cancer Risk

Commentary: Additional strong evidence that optimal serum 25-hydroxyvitamin D levels are at least 75 nmol/l

The study by Ford et al.1 offers further evidence that higher serum 25-hydroxyvitamin D [25(OH)D] levels are associated with reduced mortality rates. They found a 7% reduction [95% confidence interval…

Continue ReadingCommentary: Additional strong evidence that optimal serum 25-hydroxyvitamin D levels are at least 75 nmol/l