Cell cycle deregulation and genomic instability play a major role in the aberrant cell proliferation that characterizes tumorigenesis. A novel role of the cyclin E isoform cyclin E2 in these…
Increased oxidative stress and inflammation causally contribute to cardiovascular diseases, for which advanced age is a major risk factor. We found that indicators of oxidative stress, including NADPH oxidase activity…
Type 2 Diabetes Mellitus (T2DM) which is characterised by insulin resistance, is closely linked to the triad of glucolipotoxicity, inflammation and oxidative stress. Increased adiposity, leading to increased free fatty…
Alpha-lipoic acid (ALA) and vitamin E (VE) are normally present in human diet and their side-effects derived from oral supplementation are very rare. Interestingly, a combination of these antioxidants has…