Carcinogenic heavy metals, As3+ and Cr6+, increase affinity of nuclear mono-ubiquitinated annexin A1 for DNA containing 8-oxo-guanosine, and promote translesion DNA synthesis

To elucidate the biological roles of mono-ubiquitinated annexin A1 in nuclei, we investigated the interaction of purified nuclear mono-ubiquitinated annexin A1 with intact and oxidatively damaged DNA. We synthesized the…

Continue ReadingCarcinogenic heavy metals, As3+ and Cr6+, increase affinity of nuclear mono-ubiquitinated annexin A1 for DNA containing 8-oxo-guanosine, and promote translesion DNA synthesis

Investigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls

Background Gastrointestinal cancer is one of the most common types of cancer which is predominantly associated with the environmental factors. The carcinogenic processes are linked with the imbalances of trace…

Continue ReadingInvestigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls

Lead Exposure: A Contributing Cause of the Current Breast Cancer Epidemic in Nigerian Women

Breast cancer incidence in Nigerian women has significantly increased during the past three decades in parallel with the rapid industrialization of that country. This suggested that the associated widespread contamination…

Continue ReadingLead Exposure: A Contributing Cause of the Current Breast Cancer Epidemic in Nigerian Women