Health effects and exposure to polychlorinated biphenyls (PCBs) and metals in a contaminated community

Environmental measurements carried out by local authorities during the 1970s, 80s and 90s in an area contaminated by hundreds of years of industrial activities have revealed high levels of zinc…

Continue ReadingHealth effects and exposure to polychlorinated biphenyls (PCBs) and metals in a contaminated community

Carcinogenic heavy metals, As3+ and Cr6+, increase affinity of nuclear mono-ubiquitinated annexin A1 for DNA containing 8-oxo-guanosine, and promote translesion DNA synthesis

To elucidate the biological roles of mono-ubiquitinated annexin A1 in nuclei, we investigated the interaction of purified nuclear mono-ubiquitinated annexin A1 with intact and oxidatively damaged DNA. We synthesized the…

Continue ReadingCarcinogenic heavy metals, As3+ and Cr6+, increase affinity of nuclear mono-ubiquitinated annexin A1 for DNA containing 8-oxo-guanosine, and promote translesion DNA synthesis

Investigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls

Background Gastrointestinal cancer is one of the most common types of cancer which is predominantly associated with the environmental factors. The carcinogenic processes are linked with the imbalances of trace…

Continue ReadingInvestigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls