Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study

Objective: To examine whether 3 months of lipoic acid (LA) supplementation improved walking tolerance and delayed claudication pain onset in peripheral arterial disease (PAD). Design: Randomized, double-blind, controlled study. Setting:…

Continue ReadingEffects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study

Lipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein E–Deficient Mice Fed High-Fat/Low-Cholesterol Diet

Considerable evidence indicates that hyperglycemia increases oxidative stress and contributes to the increased incidence of atherosclerosis and cardiovascular complications in diabetic patients. To examine the effect of -lipoic acid, a…

Continue ReadingLipoic Acid Prevents the Increase in Atherosclerosis Induced by Diabetes in Apolipoprotein E–Deficient Mice Fed High-Fat/Low-Cholesterol Diet

The use of magnesium sulfate in acute asthma: Rapid uptake of evidence in North American emergency departments

Background Systematic reviews of approximately 13 randomized trials support treatment with intravenous magnesium sulfate (MgSO4) in patients with severe acute asthma; however, little is known about its actual clinical use.…

Continue ReadingThe use of magnesium sulfate in acute asthma: Rapid uptake of evidence in North American emergency departments