Protective Role of Glutathione on Alpha 1 Proteinase Inhibitor Inactivation by the Myeloperoxidase System. Hypothetic Study for Therapeutic Strategy in the Management of Smokers’ Emphysema.
In smoking subjects with obvious emphysema, the interaction between neutrophil-derived MPO and H2O2 produced by alveolar inflammatory cells (alveolar macrophages (AM) and polymorphonuclear neutrophils (PMN)) has the ability to spontaneously…