Monthly Archives: October 2008

Arsenic ingestion and increased microvascular disease risk: observations from the south-western arseniasis-endemic area in Taiwan

Background We established the association between arsenic ingestion and increased risk of vascular diseases associated with diabetes. However, the specific microvascular diseases in relation to arsenic exposure level have not…

Continue ReadingArsenic ingestion and increased microvascular disease risk: observations from the south-western arseniasis-endemic area in Taiwan

Increased Mortality from Lung Cancer and Bronchiectasis in Young Adults after Exposure to Arsenic in Utero and in Early Childhood

Arsenic in drinking water is an established cause of lung cancer, and preliminary evidence suggests that ingested arsenic may also cause nonmalignant lung disease. Antofagasta is the second largest city…

Continue ReadingIncreased Mortality from Lung Cancer and Bronchiectasis in Young Adults after Exposure to Arsenic in Utero and in Early Childhood

CHILDHOOD EXPOSURE TO ARSENIC IN WATER IN CHILE AND INCREASED MORTALITY FROM CHRONIC PULMONARY DISEASE

Introduction: Arsenic in drinking water has been established to increase lung cancer mortality rates and recent evidence also demonstrates elevated incidence and mortality from chronic obstructive pulmonary disease (COPD). In…

Continue ReadingCHILDHOOD EXPOSURE TO ARSENIC IN WATER IN CHILE AND INCREASED MORTALITY FROM CHRONIC PULMONARY DISEASE

Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer’s and Parkinson’s diseases.

There are two functional Omega class glutathione transferase (GST) genes in humans. GSTO1 is polymorphic with several coding region alleles, including an A140D substitution, a potential deletion of E155 and…

Continue ReadingCharacterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer’s and Parkinson’s diseases.