Metal-catalyzed hydroxyl radicals are potent mediators of cellular injury, affecting every category of macromolecule, and are central to the oxidative injury hypothesis of Alzheimer disease (AD) pathogenesis. Studies on redox-competent…
In this study, five heavy metals in canned tuna fish were determined after digestion by the Association of Official Analytical Chemists methods. Mercury and arsenic levels in canned tuna fish…
Metallothionein (MT) is a low–molecular weight, cysteine-rich stress response protein with a high affinity for divalent heavy metals. MT was originally identified as a cadmium-rich protein in the equine renal…
In the mitochondrial pathway of apoptosis, caspase activation is closely linked to mitochondrial outer membrane permeabilization (MOMP). Numerous pro-apoptotic signal-transducing molecules and pathological stimuli converge on mitochondria to induce MOMP.…