Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

In patients with osteoarthritis (OA), bone marrow lesions (BMLs) are intimately linked to disease progression. We hypothesized that aberrant multipotential stromal cell (also known as mesenchymal stem cell [MSC]) responses…

Continue ReadingMesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

AB0095 By intravenous infusion marked by green fluorescent protein to reveal bone marrow mesenchymal stem cells’ distribution and differentiation of collagen induced arthritis rats

Background Rheumatoid arthritis (RA) is a autoimmune disease,which is characterized by the osteoclasia or the high deformity rate of cartilage and bone. According to some materials, Mesenchymal stem cells (MSCs)…

Continue ReadingAB0095 By intravenous infusion marked by green fluorescent protein to reveal bone marrow mesenchymal stem cells’ distribution and differentiation of collagen induced arthritis rats

Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis

Mesenchymal stem cells (MSCs) are multipotent cells with the capacity to undergo chondrogenic differentiation. Systemically administered MSCs have been shown to preferentially accumulate at sites of tissue damage and inflammation,…

Continue ReadingHoming of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis

Arterial regeneration and clinical improvement of secondary autoimmune Raynaud’s syndrome with autologous bone marrow mononuclear cells (aBM-MNC). early results of phase II clinical trial

Raynaud phenomenon is chronic vasospasm of the fingers, ears, nose and toes that occurs in response to stress or cold exposure, with a prevalence rates of 11% in women and…

Continue ReadingArterial regeneration and clinical improvement of secondary autoimmune Raynaud’s syndrome with autologous bone marrow mononuclear cells (aBM-MNC). early results of phase II clinical trial