Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis

Mesenchymal stem cells (MSCs) are multipotent cells with the capacity to undergo chondrogenic differentiation. Systemically administered MSCs have been shown to preferentially accumulate at sites of tissue damage and inflammation,…

Continue ReadingHoming of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis

AB0095 By intravenous infusion marked by green fluorescent protein to reveal bone marrow mesenchymal stem cells’ distribution and differentiation of collagen induced arthritis rats

Background Rheumatoid arthritis (RA) is a autoimmune disease,which is characterized by the osteoclasia or the high deformity rate of cartilage and bone. According to some materials, Mesenchymal stem cells (MSCs)…

Continue ReadingAB0095 By intravenous infusion marked by green fluorescent protein to reveal bone marrow mesenchymal stem cells’ distribution and differentiation of collagen induced arthritis rats

Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

In patients with osteoarthritis (OA), bone marrow lesions (BMLs) are intimately linked to disease progression. We hypothesized that aberrant multipotential stromal cell (also known as mesenchymal stem cell [MSC]) responses…

Continue ReadingMesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

Impact of Autologous Bone Marrow-Derived Stem Cells on Degenerative Changes of Articulating Surfaces Associated With the Arthritic Temporomandibular Joint: An Experimental Study in Rabbits

This study evaluated the effect of bone marrow-derived stem cells (BMSCs) on degenerative changes of TMJ associated with bovine collagen type II (BCII) induced-arthritis. Materials and Methods Fifty rabbits were…

Continue ReadingImpact of Autologous Bone Marrow-Derived Stem Cells on Degenerative Changes of Articulating Surfaces Associated With the Arthritic Temporomandibular Joint: An Experimental Study in Rabbits