Lipoic acid effects on established atherosclerosis
Aims Alpha-lipoic acid (LA) is a commonly used dietary supplement that exerts anti-oxidant and anti-inflammatory effects in vivo and in vitro. We investigated the mechanisms by which LA may confer…
Lipoic acid stimulates cAMP production in T lymphocytes and NK cells
Abstract The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells…
a-Lipoic acid – the potential for use in cancer therapy
Lipoic acid (LA) is a small molecule with only two kinds of functional groups. It is a naturally-occurring co-factor present in many multi-enzyme complexes regulating metabolism. It is present in…
Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid
Abstract Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in…
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