Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease

Glutathione (GSH), a ubiquitous tripeptide thiol, is a vital intra- and extracellular protective antioxidant in the lungs. The rate-limiting enzyme in GSH synthesis is g-glutamylcysteine synthetase (g-GCS). The promoter (58-flanking)…

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Protective Role of Glutathione on Alpha 1 Proteinase Inhibitor Inactivation by the Myeloperoxidase System. Hypothetic Study for Therapeutic Strategy in the Management of Smokers’ Emphysema.

In smoking subjects with obvious emphysema, the interaction between neutrophil-derived MPO and H2O2 produced by alveolar inflammatory cells (alveolar macrophages (AM) and polymorphonuclear neutrophils (PMN)) has the ability to spontaneously…

Continue ReadingProtective Role of Glutathione on Alpha 1 Proteinase Inhibitor Inactivation by the Myeloperoxidase System. Hypothetic Study for Therapeutic Strategy in the Management of Smokers’ Emphysema.

Glutathione and Glutamate Levels in the Diaphragm of Patients with Chronic Obstructive Pulmonary Disease

Recently, decreased glutamate (Glu) and reduced glutathione (GSH) levels were reported in the quadriceps femoris of patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was…

Continue ReadingGlutathione and Glutamate Levels in the Diaphragm of Patients with Chronic Obstructive Pulmonary Disease